Cargando…

Protumorigenic Role of Elevated Levels of DNA Polymerase Epsilon Predicts an Immune-Suppressive Microenvironment in Clear Cell Renal Cell Carcinoma

Increasing evidence indicates that DNA polymerase epsilon (POLE), which mediates DNA damage repair, is significantly associated with tumor prognosis. This study aimed to analyze POLE expression in tumor samples and its prognostic value for patients with clear cell renal cell carcinoma (ccRCC). We fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Xiaohui, Tang, Haijia, Xu, Wen-Hao, Tang, Haidan, Wei, Shiyin, Anwaier, Aihetaimujiang, Huang, Haineng, Qu, Yuan-Yuan, Zhang, Hailiang, Zhao, Shuai, Li, Hui, Liu, Wangrui, Chen, Hongjing, Ding, Chen, Ye, Dingwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689073/ https://www.ncbi.nlm.nih.gov/pubmed/34950188 http://dx.doi.org/10.3389/fgene.2021.751977

Ejemplares similares

Increased DNA Polymerase Epsilon Catalytic Subunit Expression Predicts Tumor Progression and Modulates Tumor Microenvironment of Hepatocellular Carcinoma
por: Tang, Haijia, et al.
Publicado: (2022)

Tumor-associated macrophage-derived chemokine CCL5 facilitates the progression and immunosuppressive tumor microenvironment of clear cell renal cell carcinoma
por: Xu, Wenhao, et al.
Publicado: (2022)

Integrative 5-Methylcytosine Modification Immunologically Reprograms Tumor Microenvironment Characterizations and Phenotypes of Clear Cell Renal Cell Carcinoma
por: Xu, Wenhao, et al.
Publicado: (2021)

Deciphering the role of miR-187-3p/LRFN1 axis in modulating progression, aerobic glycolysis and immune microenvironment of clear cell renal cell carcinoma
por: Xu, Wenhao, et al.
Publicado: (2022)

Prognostic Immunophenotyping Clusters of Clear Cell Renal Cell Carcinoma Defined by the Unique Tumor Immune Microenvironment
por: Xu, Wenhao, et al.
Publicado: (2021)

Protein Arginine Methyltransferases Refine the Classification of Clear Cell Renal Cell Carcinoma with Distinct Prognosis and Tumor Microenvironment Characteristics
por: Ye, Shiqi, et al.
Publicado: (2023)

Multi-omics profiles refine L-dopa decarboxylase (DDC) as a reliable biomarker for prognosis and immune microenvironment of clear cell renal cell carcinoma
por: Chang, Kun, et al.
Publicado: (2022)

Special issue “The advance of solid tumor research in China”: Multi‐omics analysis based on 1311 clear cell renal cell carcinoma samples identifies a glycolysis signature associated with prognosis and treatment response
por: Tian, Xi, et al.
Publicado: (2022)

Immunogenomic Characteristics of Cell-Death-Associated Genes with Prognostic Implications in Bladder Cancer
por: Xu, Wenhao, et al.
Publicado: (2022)

Fatty Acid Synthase Correlates With Prognosis-Related Abdominal Adipose Distribution and Metabolic Disorders of Clear Cell Renal Cell Carcinoma
por: Xu, Wenhao, et al.
Publicado: (2021)

m(6)A Regulator-Mediated Methylation Modification Model Predicts Prognosis, Tumor Microenvironment Characterizations and Response to Immunotherapies of Clear Cell Renal Cell Carcinoma
por: Xu, Wenhao, et al.
Publicado: (2021)

Comprehensive Multi-Omics Identification of Interferon-γ Response Characteristics Reveals That RBCK1 Regulates the Immunosuppressive Microenvironment of Renal Cell Carcinoma
por: Xu, Wenhao, et al.
Publicado: (2021)

Adenylate cyclase‐activating polypeptide 1 gene methylation predicts prognosis and the immune microenvironment of bladder cancer
por: Xu, Wenhao, et al.
Publicado: (2021)

Heterogeneity in tertiary lymphoid structures predicts distinct prognosis and immune microenvironment characterizations of clear cell renal cell carcinoma
por: Xu, Wenhao, et al.
Publicado: (2023)

Genomic alteration of MTAP/CDKN2A predicts sarcomatoid differentiation and poor prognosis and modulates response to immune checkpoint blockade in renal cell carcinoma
por: Xu, Wenhao, et al.
Publicado: (2022)

Multi-omics reveals novel prognostic implication of SRC protein expression in bladder cancer and its correlation with immunotherapy response
por: Xu, Wenhao, et al.
Publicado: (2021)

A novel amino acid metabolism-related gene risk signature for predicting prognosis in clear cell renal cell carcinoma
por: Su, Jiaqi, et al.
Publicado: (2022)

Proteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor
por: Zhang, Hailiang, et al.
Publicado: (2023)

Real-world data on the efficacy and safety of pazopanib in IMDC favorable- and intermediate-risk metastatic renal cell carcinoma: a multicenter retrospective cohort study of Chinese patients
por: Anwaier, Aihetaimujiang, et al.
Publicado: (2022)

Elevated DNA Polymerase Delta 1 Expression Correlates With Tumor Progression and Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma
por: Zhao, Shuai, et al.
Publicado: (2021)

Traditional Chinese medicine Bu-Shen-Jian-Pi-Fang attenuates glycolysis and immune escape in clear cell renal cell carcinoma: results based on network pharmacology
por: Zheng, Jinzhou, et al.
Publicado: (2021)

Identification of tumor-infiltrating immune cells and prognostic validation of tumor-infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real-world data
por: Tian, Xi, et al.
Publicado: (2020)

Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment
por: Xu, Wenhao, et al.
Publicado: (2021)

Lipid accumulation in macrophages confers protumorigenic polarization and immunity in gastric cancer
por: Luo, Qin, et al.
Publicado: (2020)

Polymerase Epsilon-Associated Ultramutagenesis in Cancer
por: Xing, XuanXuan, et al.
Publicado: (2022)

Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes
por: Fordyce, Colleen A, et al.
Publicado: (2012)

Integrating m6A Regulators-Mediated Methylation Modification Models and Tumor Immune Microenvironment Characterization in Caucasian and Chinese Low-Grade Gliomas
por: Liu, Wangrui, et al.
Publicado: (2021)

Transcriptome Profiles Reveal a 12-Signature Metabolic Prediction Model and a Novel Role of Myo-Inositol Oxygenase in the Progression of Prostate Cancer
por: Liu, Wangrui, et al.
Publicado: (2022)

The Inflammasomes Adaptor Protein PYCARD Is a Potential Pyroptosis Biomarker Related to Immune Response and Prognosis in Clear Cell Renal Cell Carcinoma
por: Su, Jia-Qi, et al.
Publicado: (2022)

Malignant Tumor Purity Reveals the Driven and Prognostic Role of CD3E in Low-Grade Glioma Microenvironment
por: Lu, Xiuqin, et al.
Publicado: (2021)

DNA-PKcs: A Targetable Protumorigenic Protein Kinase
por: Dylgjeri, Emanuela, et al.
Publicado: (2022)

The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma
por: Huang, Bin, et al.
Publicado: (2011)

Bone Morphogenetic Protein 13 Has Protumorigenic Effects on Hepatocellular Carcinoma Cells In Vitro
por: Kersten, Vanessa, et al.
Publicado: (2023)

Shifting the Soil: Metformin Treatment Decreases the Protumorigenic Tumor Microenvironment in Epithelial Ovarian Cancer
por: Taylor, Sarah E., et al.
Publicado: (2022)

Obesity Does Not Exacerbate the Protumorigenic Systemic Environment in Sarcoma Subjects
por: Buchta, Claire M., et al.
Publicado: (2017)

The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells
por: Vipat, Sameera, et al.
Publicado: (2022)

DNA polymerase epsilon is required for heterochromatin maintenance in Arabidopsis
por: Bourguet, Pierre, et al.
Publicado: (2020)

Large‐scale transcriptome profiles reveal robust 20‐signatures metabolic prediction models and novel role of G6PC in clear cell renal cell carcinoma
por: Xu, Wen‐Hao, et al.
Publicado: (2020)

Elevated double-strand break repair protein RAD50 predicts poor prognosis in hepatitis B virus-related hepatocellular carcinoma: A study based on Chinese high-risk cohorts
por: Liu, Wangrui, et al.
Publicado: (2020)

Proteogenomic characterization of MiT family translocation renal cell carcinoma
por: Qu, Yuanyuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cee2irqsn074s8ecp5rihkr01u