Population Pharmacokinetic Model Development of Tacrolimus in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplantation

Background: With a notably narrow therapeutic window and wide intra- and interindividual pharmacokinetic (PK) variability, initial weight-based dosing along with routine therapeutic drug monitoring of tacrolimus are employed to optimize its clinical utilization. Both supratherapeutic and subtherapeu...

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Detalles Bibliográficos
Autores principales: Brooks, Jordan T., Keizer, Ron J., Long-Boyle, Janel R., Kharbanda, Sandhya, Dvorak, Christopher C., Friend, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689075/
https://www.ncbi.nlm.nih.gov/pubmed/34950026
http://dx.doi.org/10.3389/fphar.2021.750672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689075/
https://www.ncbi.nlm.nih.gov/pubmed/34950026
http://dx.doi.org/10.3389/fphar.2021.750672

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