Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila

Ataxin-2 (Atx2) is a highly conserved RNA binding protein. Atx2 undergoes polyglutamine expansion leading to amyotrophic lateral sclerosis (ALS) or spinocerebellar ataxia type 2 (SCA2). However, the physiological functions of Atx2 in neurons remain unknown. Here, using the powerful genetics of Droso...

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Detalles Bibliográficos
Autores principales: del Castillo, Urko, Norkett, Rosalind, Lu, Wen, Serpinskaya, Anna, Gelfand, Vladimir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689088/
https://www.ncbi.nlm.nih.gov/pubmed/34977501
http://dx.doi.org/10.1016/j.isci.2021.103536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689088/
https://www.ncbi.nlm.nih.gov/pubmed/34977501
http://dx.doi.org/10.1016/j.isci.2021.103536

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