(+)-9-Trifluoroethoxy-α-Dihydrotetrabenazine as a Highly Potent Vesicular Monoamine Transporter 2 Inhibitor for Tardive Dyskinesia

Valbenazine and deutetrabenazine are the only two therapeutic drugs approved for tardive dyskinesia based on blocking the action of vesicular monoamine transporter 2 (VMAT2). But there exist demethylated inactive metabolism at the nine position for both them resulting in low availability, and CYP2D6...

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Detalles Bibliográficos
Autores principales: Wang, Wenyan, Du, Guangying, Lin, Shilan, Liu, Jing, Yang, Huijie, Yu, Dawei, Ye, Liang, Zou, Fangxia, Wang, Hongbo, Zhang, Rui, Tian, Jingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689140/
https://www.ncbi.nlm.nih.gov/pubmed/34950030
http://dx.doi.org/10.3389/fphar.2021.770377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689140/
https://www.ncbi.nlm.nih.gov/pubmed/34950030
http://dx.doi.org/10.3389/fphar.2021.770377

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