Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats

Uromodulin (UMOD) is the most abundant renal protein secreted into urine by the thick ascending limb (TAL) epithelial cells of the loop of Henle. Genetic studies have demonstrated an association between UMOD risk variants and hypertension. We aimed to dissect the role of dietary salt in renal UMOD e...

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Detalles Bibliográficos
Autores principales: Mary, Sheon, Boder, Philipp, Rossitto, Giacomo, Graham, Lesley, Scott, Kayley, Flynn, Arun, Kipgen, David, Graham, Delyth, Delles, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Cardiovascular System & Vascular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689196/
https://www.ncbi.nlm.nih.gov/pubmed/34870708
http://dx.doi.org/10.1042/CS20211017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689196/
https://www.ncbi.nlm.nih.gov/pubmed/34870708
http://dx.doi.org/10.1042/CS20211017

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