USP10 inhibits the dopamine-induced reactive oxygen species–dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity

Nrf2 is an antioxidant transcriptional activator in many types of cells, and its dysfunction plays key roles in a variety of human disorders, including Parkinson's disease (PD). PD is characterized by the selective loss of dopaminergic neurons in PD-affected brain regions. Dopamine treatment of...

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Detalles Bibliográficos
Autores principales: Sango, Junya, Kakihana, Taichi, Takahashi, Masahiko, Katsuragi, Yoshinori, Anisimov, Sergei, Komatsu, Masaaki, Fujii, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689211/
https://www.ncbi.nlm.nih.gov/pubmed/34838592
http://dx.doi.org/10.1016/j.jbc.2021.101448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689211/
https://www.ncbi.nlm.nih.gov/pubmed/34838592
http://dx.doi.org/10.1016/j.jbc.2021.101448

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