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High-Throughput CRISPR Screens To Dissect Macrophage-Shigella Interactions

Shigellosis causes most diarrheal deaths worldwide, particularly affecting children. Shigella invades and replicates in the epithelium of the large intestine, eliciting inflammation and tissue destruction. To understand how Shigella rewires macrophages prior to epithelium invasion, we performed geno...

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Detalles Bibliográficos
Autores principales:	Lai, Yong, Cui, Liang, Babunovic, Gregory H., Fortune, Sarah M., Doench, John G., Lu, Timothy K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689513/ https://www.ncbi.nlm.nih.gov/pubmed/34933448 http://dx.doi.org/10.1128/mBio.02158-21

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