Cargando…

A J Domain Protein Functions as a Histone Chaperone to Maintain Genome Integrity and the Response to DNA Damage in a Human Fungal Pathogen

Histone chaperoning ensures genomic integrity during routine processes such as DNA replication and transcription as well as DNA repair upon damage. Here, we identify a nuclear J domain protein, Dnj4, in the fungal pathogen Cryptococcus neoformans and demonstrate that it interacts with histones 3 and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Horianopoulos, Linda C., Lee, Christopher W. J., Schmitt, Kerstin, Valerius, Oliver, Hu, Guanggan, Caza, Mélissa, Braus, Gerhard H., Kronstad, James W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689522/ https://www.ncbi.nlm.nih.gov/pubmed/34933457 http://dx.doi.org/10.1128/mbio.03273-21

Ejemplares similares

The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in Cryptococcus neoformans
por: Horianopoulos, Linda C., et al.
Publicado: (2020)

Dnj1 Promotes Virulence in Cryptococcus neoformans by Maintaining Robust Endoplasmic Reticulum Homeostasis Under Temperature Stress
por: Horianopoulos, Linda C., et al.
Publicado: (2021)

Chaperone Networks in Fungal Pathogens of Humans
por: Horianopoulos, Linda C., et al.
Publicado: (2021)

The monothiol glutaredoxin Grx4 influences thermotolerance, cell wall integrity, and Mpk1 signaling in Cryptococcus neoformans
por: Hu, Guanggan, et al.
Publicado: (2021)

Involvement of Mrs3/4 in Mitochondrial Iron Transport and Metabolism in Cryptococcus neoformans
por: Choi, Yoojeong, et al.
Publicado: (2020)

Proteasome inhibition as a therapeutic target for the fungal pathogen Cryptococcus neoformans
por: Caza, Mélissa, et al.
Publicado: (2023)

Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans
por: Caza, Mélissa, et al.
Publicado: (2013)

The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans
por: Caza, Mélissa, et al.
Publicado: (2016)

The histone chaperone DAXX maintains the structural organization of heterochromatin domains
por: Rapkin, Lindsy M., et al.
Publicado: (2015)

COP9 Signalosome Interaction with UspA/Usp15 Deubiquitinase Controls VeA-Mediated Fungal Multicellular Development
por: Meister, Cindy, et al.
Publicado: (2019)

The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence
por: Jenull, Sabrina, et al.
Publicado: (2021)

Respiring to infect: Emerging links between mitochondria, the electron transport chain, and fungal pathogenesis
por: Black, Braydon, et al.
Publicado: (2021)

The Sec1/Munc18 (SM) protein Vps45 is involved in iron uptake, mitochondrial function and virulence in the pathogenic fungus Cryptococcus neoformans
por: Caza, Mélissa, et al.
Publicado: (2018)

The cAMP/Protein Kinase A Pathway and Virulence in Cryptococcus neoformans
por: Kronstad, James W., et al.
Publicado: (2011)

The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans
por: Caza, Mélissa, et al.
Publicado: (2019)

Vacuole fragmentation depends on a novel Atg18-containing retromer-complex
por: Marquardt, Lisa, et al.
Publicado: (2022)

Fungal COP9 signalosome assembly requires connection of two trimeric intermediates for integration of intrinsic deneddylase
por: Bakti, Fruzsina, et al.
Publicado: (2023)

Extracellular chaperone networks and the export of J-domain proteins
por: Braun, Janice E.A.
Publicado: (2022)

The DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal Development
por: Schinke, Josua, et al.
Publicado: (2016)

α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast
por: Popova, Blagovesta, et al.
Publicado: (2021)

The Frq–Frh Complex Light-Dependently Delays Sfl1-Induced Microsclerotia Formation in Verticillium dahliae
por: Nagel, Alexandra, et al.
Publicado: (2023)

Verticillium dahliae Vta3 promotes ELV1 virulence factor gene expression in xylem sap, but tames Mtf1-mediated late stages of fungus-plant interactions and microsclerotia formation
por: Maurus, Isabel, et al.
Publicado: (2023)

Erratum for Attarian et al., “The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans”
por: Attarian, Rodgoun, et al.
Publicado: (2019)

The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans
por: Attarian, Rodgoun, et al.
Publicado: (2018)

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF
por: Corbeski, Ivan, et al.
Publicado: (2022)

Histone Chaperone Asf1 Plays an Essential Role in Maintaining Genomic Stability in Fission Yeast
por: Tanae, Katsuhiro, et al.
Publicado: (2012)

NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape
por: Holmberg Olausson, Karl, et al.
Publicado: (2015)

The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo
por: Tirgar, Reyhaneh, et al.
Publicado: (2023)

AtFKBP53: a chimeric histone chaperone with functional nucleoplasmin and PPIase domains
por: Singh, Ajit Kumar, et al.
Publicado: (2020)

LaeA Control of Velvet Family Regulatory Proteins for Light-Dependent Development and Fungal Cell-Type Specificity
por: Sarikaya Bayram, Özlem, et al.
Publicado: (2010)

Manipulation of fungal development as source of novel secondary metabolites for biotechnology
por: Gerke, Jennifer, et al.
Publicado: (2014)

Structure of the human histone chaperone FACT Spt16 N-terminal domain
por: Marcianò, G., et al.
Publicado: (2016)

A potential histone-chaperone activity for the MIER1 histone deacetylase complex
por: Wang, Siyu, et al.
Publicado: (2023)

Histone acetylation-independent transcription stimulation by a histone chaperone
por: Kato, Kohsuke, et al.
Publicado: (2007)

The velvet protein Vel1 controls initial plant root colonization and conidia formation for xylem distribution in Verticillium wilt
por: Höfer, Annalena M., et al.
Publicado: (2021)

Histone chaperone regulates replication
por: Robinson, Richard
Publicado: (2008)

The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells
por: Ng, Charles, et al.
Publicado: (2019)

Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus
por: Bardetti, Paola, et al.
Publicado: (2019)

Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans
por: Hu, Guanggan, et al.
Publicado: (2008)

Secondary metabolites of Hülle cells mediate protection of fungal reproductive and overwintering structures against fungivorous animals
por: Liu, Li, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lhb7h5vbdl85e3enrpv1pnfbs2