Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2

[Image: see text] The extracellular accumulation of glutamate is a pathologic hallmark of numerous neurodegenerative diseases including ischemic stroke and Alzheimer’s disease. At high extracellular concentrations, glutamate causes neuronal damage by promoting oxidative stress, which can lead to cel...

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Detalles Bibliográficos
Autores principales: Rosarda, Jessica D., Baron, Kelsey R., Nutsch, Kayla, Kline, Gabriel M., Stanton, Caroline, Kelly, Jeffery W., Bollong, Michael J., Wiseman, R. Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689639/
https://www.ncbi.nlm.nih.gov/pubmed/34797633
http://dx.doi.org/10.1021/acschembio.1c00810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689639/
https://www.ncbi.nlm.nih.gov/pubmed/34797633
http://dx.doi.org/10.1021/acschembio.1c00810

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