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Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2
[Image: see text] The extracellular accumulation of glutamate is a pathologic hallmark of numerous neurodegenerative diseases including ischemic stroke and Alzheimer’s disease. At high extracellular concentrations, glutamate causes neuronal damage by promoting oxidative stress, which can lead to cel...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689639/ https://www.ncbi.nlm.nih.gov/pubmed/34797633 http://dx.doi.org/10.1021/acschembio.1c00810 |