An Orthogonally Protected Cyclitol for the Construction of Nigerose- and Dextran-Mimetic Cyclophellitols

[Image: see text] Cyclophellitols are potent inhibitors of exo- and endoglycosidases. Efficient synthetic methodologies are needed to fully capitalize on this intriguing class of mechanism-based enzyme deactivators. We report the synthesis of an orthogonally protected cyclitol from d-glucal (19% yie...

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Detalles Bibliográficos
Autores principales: Ofman, Tim P., Küllmer, Florian, van der Marel, Gijsbert A., Codée, Jeroen D. C., Overkleeft, Herman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689644/
https://www.ncbi.nlm.nih.gov/pubmed/34846911
http://dx.doi.org/10.1021/acs.orglett.1c03723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689644/
https://www.ncbi.nlm.nih.gov/pubmed/34846911
http://dx.doi.org/10.1021/acs.orglett.1c03723

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