Synthesis of Azacarbolines via PhIO(2)-Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones

[Image: see text] An unprecedented synthesis of polysubstituted indole-fused pyridazines (azacarbolines) from α-indolylhydrazones under oxidative conditions using a combination of iodylbenzene (PhIO(2)) and trifluoroacetic acid (TFA) has been developed. This transformation is conducted without the n...

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Autores principales: Corrieri, Matteo, De Crescentini, Lucia, Mantellini, Fabio, Mari, Giacomo, Santeusanio, Stefania, Favi, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689645/
https://www.ncbi.nlm.nih.gov/pubmed/34871002
http://dx.doi.org/10.1021/acs.joc.1c02217
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author Corrieri, Matteo
De Crescentini, Lucia
Mantellini, Fabio
Mari, Giacomo
Santeusanio, Stefania
Favi, Gianfranco
author_facet Corrieri, Matteo
De Crescentini, Lucia
Mantellini, Fabio
Mari, Giacomo
Santeusanio, Stefania
Favi, Gianfranco
author_sort Corrieri, Matteo
collection PubMed
description [Image: see text] An unprecedented synthesis of polysubstituted indole-fused pyridazines (azacarbolines) from α-indolylhydrazones under oxidative conditions using a combination of iodylbenzene (PhIO(2)) and trifluoroacetic acid (TFA) has been developed. This transformation is conducted without the need for transition metals, harsh conditions, or an inert atmosphere.
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spelling pubmed-86896452021-12-22 Synthesis of Azacarbolines via PhIO(2)-Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones Corrieri, Matteo De Crescentini, Lucia Mantellini, Fabio Mari, Giacomo Santeusanio, Stefania Favi, Gianfranco J Org Chem [Image: see text] An unprecedented synthesis of polysubstituted indole-fused pyridazines (azacarbolines) from α-indolylhydrazones under oxidative conditions using a combination of iodylbenzene (PhIO(2)) and trifluoroacetic acid (TFA) has been developed. This transformation is conducted without the need for transition metals, harsh conditions, or an inert atmosphere. American Chemical Society 2021-12-06 2021-12-17 /pmc/articles/PMC8689645/ /pubmed/34871002 http://dx.doi.org/10.1021/acs.joc.1c02217 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Corrieri, Matteo
De Crescentini, Lucia
Mantellini, Fabio
Mari, Giacomo
Santeusanio, Stefania
Favi, Gianfranco
Synthesis of Azacarbolines via PhIO(2)-Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones
title Synthesis of Azacarbolines via PhIO(2)-Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones
title_full Synthesis of Azacarbolines via PhIO(2)-Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones
title_fullStr Synthesis of Azacarbolines via PhIO(2)-Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones
title_full_unstemmed Synthesis of Azacarbolines via PhIO(2)-Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones
title_short Synthesis of Azacarbolines via PhIO(2)-Promoted Intramolecular Oxidative Cyclization of α-Indolylhydrazones
title_sort synthesis of azacarbolines via phio(2)-promoted intramolecular oxidative cyclization of α-indolylhydrazones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689645/
https://www.ncbi.nlm.nih.gov/pubmed/34871002
http://dx.doi.org/10.1021/acs.joc.1c02217
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