Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover

[Image: see text] Uncovering the role of global protein dynamics in enzyme turnover is needed to fully understand enzyme catalysis. Recently, we have demonstrated that the heat capacity of catalysis, ΔC(P)(‡), can reveal links between the protein free energy landscape, global protein dynamics, and e...

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Detalles Bibliográficos
Autores principales: Winter, Samuel D., Jones, Hannah B. L., Răsădean, Dora M., Crean, Rory M., Danson, Michael J., Pantoş, G. Dan, Katona, Gergely, Prentice, Erica, Arcus, Vickery L., van der Kamp, Marc W., Pudney, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689651/
https://www.ncbi.nlm.nih.gov/pubmed/34956689
http://dx.doi.org/10.1021/acscatal.1c04679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689651/
https://www.ncbi.nlm.nih.gov/pubmed/34956689
http://dx.doi.org/10.1021/acscatal.1c04679

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