mTEC damage risks immune recovery

Whether autologous hematopoietic stem cell transplantation is free from graft-versus-host disease is controversial. Alawam et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211239) now demonstrate that prolonged damage in thymic medullary epithelial cells causes the failure in self-tolerance...

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Detalles Bibliográficos
Autor principal: Takahama, Yousuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689664/
https://www.ncbi.nlm.nih.gov/pubmed/34919145
http://dx.doi.org/10.1084/jem.20212326
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author Takahama, Yousuke
author_facet Takahama, Yousuke
author_sort Takahama, Yousuke
collection PubMed
description Whether autologous hematopoietic stem cell transplantation is free from graft-versus-host disease is controversial. Alawam et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211239) now demonstrate that prolonged damage in thymic medullary epithelial cells causes the failure in self-tolerance in newly generated T cells and provokes post-transplant autoimmunity.
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spelling pubmed-86896642022-07-14 mTEC damage risks immune recovery Takahama, Yousuke J Exp Med Insights Whether autologous hematopoietic stem cell transplantation is free from graft-versus-host disease is controversial. Alawam et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20211239) now demonstrate that prolonged damage in thymic medullary epithelial cells causes the failure in self-tolerance in newly generated T cells and provokes post-transplant autoimmunity. Rockefeller University Press 2021-12-17 /pmc/articles/PMC8689664/ /pubmed/34919145 http://dx.doi.org/10.1084/jem.20212326 Text en © 2021 Takahama https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Takahama, Yousuke
mTEC damage risks immune recovery
title mTEC damage risks immune recovery
title_full mTEC damage risks immune recovery
title_fullStr mTEC damage risks immune recovery
title_full_unstemmed mTEC damage risks immune recovery
title_short mTEC damage risks immune recovery
title_sort mtec damage risks immune recovery
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689664/
https://www.ncbi.nlm.nih.gov/pubmed/34919145
http://dx.doi.org/10.1084/jem.20212326
work_keys_str_mv AT takahamayousuke mtecdamagerisksimmunerecovery

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