Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo

Progranulin is a lysosomal protein whose haploinsufficiency causes frontotemporal dementia, while homozygous loss of progranulin causes neuronal ceroid lipofuscinosis, a lysosomal storage disease. The sensitivity of cells to progranulin deficiency raises important questions about how cells coordinat...

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Detalles Bibliográficos
Autores principales: Devireddy, Swathi, Ferguson, Shawn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689666/
https://www.ncbi.nlm.nih.gov/pubmed/34919127
http://dx.doi.org/10.1083/jcb.202104044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689666/
https://www.ncbi.nlm.nih.gov/pubmed/34919127
http://dx.doi.org/10.1083/jcb.202104044

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