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Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo
Progranulin is a lysosomal protein whose haploinsufficiency causes frontotemporal dementia, while homozygous loss of progranulin causes neuronal ceroid lipofuscinosis, a lysosomal storage disease. The sensitivity of cells to progranulin deficiency raises important questions about how cells coordinat...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689666/ https://www.ncbi.nlm.nih.gov/pubmed/34919127 http://dx.doi.org/10.1083/jcb.202104044 |