Role of Secretoglobin(+) (club cell) NFκB/RelA-TGFβ signaling in aero-allergen-induced epithelial plasticity and subepithelial myofibroblast transdifferentiation

Repetitive aeroallergen exposure is linked to sensitization and airway remodeling through incompletely understood mechanisms. In this study, we examine the dynamic mucosal response to cat dander extract (CDE), a ubiquitous aero-allergen linked to remodeling, sensitization and asthma. We find that da...

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Detalles Bibliográficos
Autores principales: Skibba, Melissa E., Xu, Xiaofang, Weiss, Kurt, Huisken, Jan, Brasier, Allan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690490/
https://www.ncbi.nlm.nih.gov/pubmed/34930252
http://dx.doi.org/10.1186/s12931-021-01910-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690490/
https://www.ncbi.nlm.nih.gov/pubmed/34930252
http://dx.doi.org/10.1186/s12931-021-01910-w

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