499. Rapid and Sustained Decline in CXCL-10 (IP-10) Annotates Clinical Outcomes Following TNF-α Antagonist Therapy in Hospitalized Patients with Severe and Critical COVID-19 Respiratory Failure

BACKGROUND: TNFα and IFN-γ may synergize to induce cytokine-driven lethal hyperinflammation and immune exhaustion in COVID-19 illness. METHODS: To assess TNFα-antagonist therapy, 18 hospitalized adults with hypoxic respiratory failure and COVID-19 pneumonia received single-dose infliximab-abda thera...

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Detalles Bibliográficos
Autores principales: Schroeder, Courtney, Hachem, Hilal, Godara, Amandeep, Fein, Daniel, Mann, Hashim, Lawlor, Christian, Marshall, Jill, Klein, Andreas, Poutsiaka, Debra, Breeze, Janis, Joshi, Raghav, Mathew, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Poster Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690667/
http://dx.doi.org/10.1093/ofid/ofab466.698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690667/
http://dx.doi.org/10.1093/ofid/ofab466.698

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