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Adaptive Evolution in TRIF Leads to Discordance between Human and Mouse Innate Immune Signaling

The TIR domain-containing adapter inducing IFN-β (TRIF) protein is an innate immune system protein that mediates the MyD88-independent toll-like receptor response pathway in mice and humans. Previously, we identified positive selection at seven distinct residues in mouse TRIF (mTRIF), as compared wi...

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Detalles Bibliográficos
Autores principales:	Hyland, Edel M, Webb, Andrew E, Kennedy, Kathy F, Gerek Ince, Z Nevin, Loscher, Christine E, O’Connell, Mary J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691055/ https://www.ncbi.nlm.nih.gov/pubmed/34893845 http://dx.doi.org/10.1093/gbe/evab268

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