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Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice
BACKGROUND: Dynamic changes of histone posttranslational modifications are important contexts of epigenetic reprograming after fertilization in pre-implantation embryos. Recently, lactylation has been reported as a novel epigenetic modification that regulates various cellular processes, but its role...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691063/ https://www.ncbi.nlm.nih.gov/pubmed/34930415 http://dx.doi.org/10.1186/s13072-021-00431-6 |