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Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice

BACKGROUND: Dynamic changes of histone posttranslational modifications are important contexts of epigenetic reprograming after fertilization in pre-implantation embryos. Recently, lactylation has been reported as a novel epigenetic modification that regulates various cellular processes, but its role...

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Detalles Bibliográficos
Autores principales: Yang, Wanting, Wang, Peijun, Cao, Pengbo, Wang, Shuang, Yang, Yuxiao, Su, Huimin, Nashun, Buhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691063/
https://www.ncbi.nlm.nih.gov/pubmed/34930415
http://dx.doi.org/10.1186/s13072-021-00431-6