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Synthetic- and DFT modelling studies on regioselective modified Mannich reactions of hydroxy-KYNA derivatives
The syntheses of hydroxy-substituted kynurenic acid (KYNA) derivatives have been achieved by an optimised Conrad–Limpach procedure. The derivatives were then reacted with morpholine and paraformaldehyde, as a representative amine and aldehyde, in a modified Mannich reaction. The newly introduced sub...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691111/ https://www.ncbi.nlm.nih.gov/pubmed/35423050 http://dx.doi.org/10.1039/d0ra08325a |