Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T α-synuclein levels and aggregation

Inhibiting formation or promoting degradation of α-synuclein aggregates are among the therapeutical approaches under investigation as disease-modifying treatment strategies for Parkinson’s disease. To support these developments, several in vitro models based on seeded α-synuclein aggregation have be...

Descripción completa

Detalles Bibliográficos
Autores principales: Vajhøj, Charlotte, Schmid, Benjamin, Alik, Ania, Melki, Ronald, Fog, Karina, Holst, Bjørn, Stummann, Tina Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691628/
https://www.ncbi.nlm.nih.gov/pubmed/34932569
http://dx.doi.org/10.1371/journal.pone.0261536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691628/
https://www.ncbi.nlm.nih.gov/pubmed/34932569
http://dx.doi.org/10.1371/journal.pone.0261536

Ejemplares similares