IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25(+)Foxp3(-) T cells

Complexes of IL-2 and JES6-1 mAb (IL-2/JES6) provide strong sustained IL-2 signal selective for CD25(+) cells and thus they potently expand T(reg) cells. IL-2/JES6 are effective in the treatment of autoimmune diseases and in protecting against rejection of pancreatic islet allografts. However, we fo...

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Detalles Bibliográficos
Autores principales: Tomala, Jakub, Weberova, Petra, Tomalova, Barbora, Jiraskova Zakostelska, Zuzana, Sivak, Ladislav, Kovarova, Jirina, Kovar, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691839/
https://www.ncbi.nlm.nih.gov/pubmed/34932467
http://dx.doi.org/10.7554/eLife.62432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691839/
https://www.ncbi.nlm.nih.gov/pubmed/34932467
http://dx.doi.org/10.7554/eLife.62432

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