Munc13-1 is a Ca(2+)-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission

During ongoing presynaptic action potential (AP) firing, transmitter release is limited by the availability of release-ready synaptic vesicles (SVs). The rate of SV recruitment (SVR) to release sites is strongly upregulated at high AP frequencies to balance SV consumption. We show that Munc13-1—an e...

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Detalles Bibliográficos
Autores principales: Lipstein, Noa, Chang, Shuwen, Lin, Kun-Han, López-Murcia, Francisco José, Neher, Erwin, Taschenberger, Holger, Brose, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691950/
https://www.ncbi.nlm.nih.gov/pubmed/34706220
http://dx.doi.org/10.1016/j.neuron.2021.09.054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8691950/
https://www.ncbi.nlm.nih.gov/pubmed/34706220
http://dx.doi.org/10.1016/j.neuron.2021.09.054

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