Cargando…

Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway

METHODS: All rats were randomly divided into four groups, namely, control, CUMS, CUMS + CUR, and CUMS + CUR + SR18292 (PGC-1α inhibitor). Behavioral tests were conducted to assess the antidepressant-like effects of CUR. The expressions of PGC-1α, estrogen-related receptor alpha (ERRα), FNDC5, and BD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Yanqin, Sun, Fusheng, Guo, Yujin, Zhang, Yumao, Li, Li, Dang, Ruili, Jiang, Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692045/ https://www.ncbi.nlm.nih.gov/pubmed/34950248 http://dx.doi.org/10.1155/2021/2630445

Ejemplares similares

Association of Irisin/FNDC5 with ERRα and PGC-1α Expression in NSCLC
por: Nowińska, Katarzyna, et al.
Publicado: (2022)

Assessment of PGC1α-FNDC5 Axis in Granulosa Cells of PCOS Mouse Model
por: Bakhshalizadeh, Shabnam, et al.
Publicado: (2018)

Avicularin Relieves Depressive-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice
por: Shen, Zhongfei, et al.
Publicado: (2019)

Fish oil supplementation alleviates depressant-like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress
por: Tang, Mimi, et al.
Publicado: (2015)

Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1α Pathway
por: Luo, Jia, et al.
Publicado: (2020)

An Association Between FNDC5, PGC-1α Genetic Variants and Obesity in Chinese Children: A Case-Control Study
por: Wang, Yuanyuan, et al.
Publicado: (2023)

Systematic impacts of chronic unpredictable mild stress on metabolomics in rats
por: Geng, Chunmei, et al.
Publicado: (2020)

β-asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal-regulated kinase signaling pathway
por: Dong, Haiying, et al.
Publicado: (2019)

Indoxyl sulfate induced frailty in patients with end-stage renal disease by disrupting the PGC-1α–FNDC5 axis
por: Hou, Yi-Chou, et al.
Publicado: (2023)

Effect of exercise training on the FNDC5/BDNF pathway in spontaneously hypertensive rats
por: Wang, Tao, et al.
Publicado: (2019)

Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior
por: Jo, Danbi, et al.
Publicado: (2021)

Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress
por: Li, Jing, et al.
Publicado: (2013)

Polygalae Radix Oligosaccharide Esters May Relieve Depressive-like Behavior in Rats with Chronic Unpredictable Mild Stress via Modulation of Gut Microbiota
por: Chen, Qijun, et al.
Publicado: (2023)

PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ(1−42) Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting Neuronal Apoptosis, Aβ Deposition and Cognitive Decline of APP/PS1 Tg Mice
por: Xia, De-Yu, et al.
Publicado: (2017)

The Acute Effects of Swimming Exercise on PGC-1α-FNDC5/Irisin-UCP1 Expression in Male C57BL/6J Mice
por: Cho, Eunhee, et al.
Publicado: (2021)

The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress-Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats
por: Shen, Jun, et al.
Publicado: (2016)

Cucurbitacin B Exerts Significant Antidepressant-Like Effects in a Chronic Unpredictable Mild Stress Model of Depression: Involvement of the Hippocampal BDNF-TrkB System
por: Ge, Jian-Bin, et al.
Publicado: (2023)

PPARγ/Pgc-1α-Fndc5 pathway up-regulation in gastrocnemius and heart muscle of exercised, branched chain amino acid diet fed mice
por: Abedpoor, Navid, et al.
Publicado: (2018)

The Impacts of Swimming Exercise on Hippocampal Expression of Neurotrophic Factors in Rats Exposed to Chronic Unpredictable Mild Stress
por: Jiang, Pei, et al.
Publicado: (2014)

Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats
por: Liao, Dehua, et al.
Publicado: (2020)

Antidepressant Effects of Rhodomyrtone in Mice with Chronic Unpredictable Mild Stress-Induced Depression
por: Chai, Huihui, et al.
Publicado: (2018)

Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway
por: Hu, Min, et al.
Publicado: (2016)

Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf
por: Clark, Joanne, et al.
Publicado: (2012)

The Antidepressant Agomelatine Improves Memory Deterioration and Upregulates CREB and BDNF Gene Expression Levels in Unpredictable Chronic Mild Stress (UCMS)-Exposed Mice
por: Gumuslu, Esen, et al.
Publicado: (2014)

Effects of Electroacupuncture at Auricular Concha Region on the Depressive Status of Unpredictable Chronic Mild Stress Rat Models
por: Liu, Ru-Peng, et al.
Publicado: (2013)

Resveratrol ameliorates chronic unpredictable mild stress-induced depression-like behavior: involvement of the HPA axis, inflammatory markers, BDNF, and Wnt/β-catenin pathway in rats
por: Yang, Xin-Hua, et al.
Publicado: (2017)

Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway
por: He, Wuyang, et al.
Publicado: (2020)

cAMP/PKA-CREB-BDNF signaling pathway in hippocampus mediates cyclooxygenase 2-induced learning/memory deficits of rats subjected to chronic unpredictable mild stress
por: Luo, Ying, et al.
Publicado: (2017)

Asiaticoside produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice, involving reversion of inflammation and the PKA/pCREB/BDNF signaling pathway
por: Wang, Luoqing, et al.
Publicado: (2020)

Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress
por: Dionisie, Vlad, et al.
Publicado: (2021)

18β-Glycyrrhetinic Acid Ameliorates Neuroinflammation Linked Depressive Behavior Instigated by Chronic Unpredictable Mild Stress via Triggering BDNF/TrkB Signaling Pathway in Rats
por: Gupta, Girdhari Lal, et al.
Publicado: (2022)

Effects of Vitamin D(3) in Long-Term Ovariectomized Rats Subjected to Chronic Unpredictable Mild Stress: BDNF, NT-3, and NT-4 Implications
por: Koshkina, Alexandra, et al.
Publicado: (2019)

Traxoprodil Produces Antidepressant-Like Behaviors in Chronic Unpredictable Mild Stress Mice through BDNF/ERK/CREB and AKT/FOXO/Bim Signaling Pathway
por: Wang, Yahui, et al.
Publicado: (2023)

Chronic Unpredictable Mild Stress in Rats Induces Colonic Inflammation
por: Wei, Lina, et al.
Publicado: (2019)

Antidepressant effect of taurine in chronic unpredictable mild stress-induced depressive rats
por: Wu, Gao-Feng, et al.
Publicado: (2017)

Effect of chronic unpredicted mild stress-induced depression on clopidogrel pharmacokinetics in rats
por: Jiang, Xueyao, et al.
Publicado: (2022)

Eight Weeks of High-Intensity Interval Static Strength Training Improves Skeletal Muscle Atrophy and Motor Function in Aged Rats via the PGC-1α/FNDC5/UCP1 Pathway
por: Liu, Yijie, et al.
Publicado: (2021)

Suppressive Effects of Isofraxidin on Depressive-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice
por: Wu, Xiaoli, et al.
Publicado: (2022)

FNDC5/Irisin: Physiology and Pathophysiology
por: Waseem, Rashid, et al.
Publicado: (2022)

Metabolomics Analysis of the Prefrontal Cortex in a Rat Chronic Unpredictable Mild Stress Model of Depression
por: Duan, Lihua, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jhmh0oj56n1qpjqhdd3ks8noae