Synthesis and multifaceted pharmacological activity of novel quinazoline NHE-1 inhibitors

The Na(+)/H(+) exchanger isoform 1 (NHE-1) attracts ongoing attention as a validated drug target for the management of cardiovascular and ocular diseases owing to cytoprotective, anti-ischemic and anti-inflammatory properties of NHE-1 inhibitors. Herein we report novel NHE-1 inhibitors realized via...

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Detalles Bibliográficos
Autores principales: Spasov, Alexander, Ozerov, Alexander, Vassiliev, Pavel, Kosolapov, Vadim, Gurova, Natalia, Kucheryavenko, Aida, Naumenko, Ludmila, Babkov, Denis, Sirotenko, Viktor, Taran, Alena, Litvinov, Roman, Borisov, Alexander, Klochkov, Vladlen, Merezhkina, Darya, Miroshnikov, Mikhail, Uskov, Georgy, Ovsyankina, Nadezhda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692498/
https://www.ncbi.nlm.nih.gov/pubmed/34934125
http://dx.doi.org/10.1038/s41598-021-03722-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692498/
https://www.ncbi.nlm.nih.gov/pubmed/34934125
http://dx.doi.org/10.1038/s41598-021-03722-w

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