Involvement of Calcium-Dependent Pathway and β Subunit-Interaction in Neuronal Migration and Callosal Projection Deficits Caused by the Cav1.2 I1166T Mutation in Developing Mouse Neocortex

Introduction: Gain-of-function mutations in the L-type Ca(2+) channel Cav1.2 cause Timothy syndrome (TS), a multisystem disorder associated with neurologic symptoms, including autism spectrum disorder (ASD), seizures, and intellectual disability. Cav1.2 plays key roles in neural development, and its...

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Detalles Bibliográficos
Autores principales: Nakagawa-Tamagawa, Nao, Kirino, Emi, Sugao, Kohtaroh, Nagata, Hidetaka, Tagawa, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692569/
https://www.ncbi.nlm.nih.gov/pubmed/34955712
http://dx.doi.org/10.3389/fnins.2021.747951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692569/
https://www.ncbi.nlm.nih.gov/pubmed/34955712
http://dx.doi.org/10.3389/fnins.2021.747951

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