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Controlled rate slow freezing with lyoprotective agent to retain the integrity of lipid nanovesicles during lyophilization
We designed a novel lyophilization method using controlled rate slow freezing (CSF) with lyoprotective agent (LPA) to achieve intact lipid nanovesicles after lyophilization. During the freezing step, LPA prevented water supercooling, and the freezing rate was controlled by CSF. Regulating the freezi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692592/ https://www.ncbi.nlm.nih.gov/pubmed/34934167 http://dx.doi.org/10.1038/s41598-021-03841-4 |