Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration

Activation of the pro-degenerative protein SARM1 after diverse physical and disease-relevant injuries causes programmed axon degeneration. Original studies indicate that substantially decreased SARM1 levels are required for neuroprotection. However, we demonstrate, in Sarm1 haploinsufficient mice, t...

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Detalles Bibliográficos
Autores principales: Gould, Stacey Anne, Gilley, Jonathan, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank, Coleman, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692746/
https://www.ncbi.nlm.nih.gov/pubmed/34910914
http://dx.doi.org/10.1016/j.celrep.2021.110108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692746/
https://www.ncbi.nlm.nih.gov/pubmed/34910914
http://dx.doi.org/10.1016/j.celrep.2021.110108

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