Modulation of H4K16Ac levels reduces pro-fibrotic gene expression and mitigates lung fibrosis in aged mice

Histone H4 lysine16 acetylation (H4K16Ac) modulates chromatin structure by serving as a switch from a repressive to a transcriptionally active state. This euchromatin mark is associated with active transcription. In this study, we investigated the effects of H4K16Ac on the expression of pro-fibrotic...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xiangyu, Liu, Hui, Zhou, Jennifer Q, Krick, Stefanie, Barnes, Jarrod W, Thannickal, Victor J, Sanders, Yan Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692895/
https://www.ncbi.nlm.nih.gov/pubmed/34976199
http://dx.doi.org/10.7150/thno.62760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692895/
https://www.ncbi.nlm.nih.gov/pubmed/34976199
http://dx.doi.org/10.7150/thno.62760

Ejemplares similares