Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes

Mycobacterium tuberculosis remains a leading cause of infectious disease morbidity and mortality for which new drug combination therapies are needed. Combinations of respiratory inhibitors can have synergistic or synthetic lethal interactions with sterilizing activity, suggesting that regimens with...

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Detalles Bibliográficos
Autores principales: McNeil, Matthew B., Ryburn, Heath W., Tirados, Justin, Cheung, Chen-Yi, Cook, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692989/
https://www.ncbi.nlm.nih.gov/pubmed/34984329
http://dx.doi.org/10.1016/j.isci.2021.103573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692989/
https://www.ncbi.nlm.nih.gov/pubmed/34984329
http://dx.doi.org/10.1016/j.isci.2021.103573

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