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Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes
Mycobacterium tuberculosis remains a leading cause of infectious disease morbidity and mortality for which new drug combination therapies are needed. Combinations of respiratory inhibitors can have synergistic or synthetic lethal interactions with sterilizing activity, suggesting that regimens with...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8692989/ https://www.ncbi.nlm.nih.gov/pubmed/34984329 http://dx.doi.org/10.1016/j.isci.2021.103573 |