Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells

Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic positions adjacent to the 3′ and 5′ ends were prepared via the Staudinger chemistry, which is compatible with conditions of standard automated soli...

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Detalles Bibliográficos
Autores principales: Kupryushkin, Maxim S., Filatov, Anton V., Mironova, Nadezhda L., Patutina, Olga A., Chernikov, Ivan V., Chernolovskaya, Elena L., Zenkova, Marina A., Pyshnyi, Dmitrii V., Stetsenko, Dmitry A., Altman, Sidney, Vlassov, Valentin V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693280/
https://www.ncbi.nlm.nih.gov/pubmed/34976439
http://dx.doi.org/10.1016/j.omtn.2021.11.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693280/
https://www.ncbi.nlm.nih.gov/pubmed/34976439
http://dx.doi.org/10.1016/j.omtn.2021.11.025

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