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The importance of intramolecular hydrogen bonds on the translocation of the small drug piracetam through a lipid bilayer
The number of hydrogen bond donors and acceptors is a fundamental molecular descriptor to predict the oral bioavailability of small drug candidates. In fact, the most widely used oral bioavailability rules (such as the Lipinsky's rule-of-five and the Veber rules) make use of this molecular desc...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693363/ https://www.ncbi.nlm.nih.gov/pubmed/35423709 http://dx.doi.org/10.1039/d0ra09995c |