Mesenchymal stem cells anchored with thymidine phosphorylase for doxifluridine-mediated cancer therapy

Many tumors express thymidine phosphorylase (TYMP) with various levels, however due to tumor heterogeneity, the amount of TYMP is usually not enough to convert prodrug doxifluridine (5′-DFUR) to toxic drug 5-fluorouracil (5-FU). Since human mesenchymal stem cells (hMSCs) have unique features of tumo...

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Detalles Bibliográficos
Autores principales: Tarar, Ammar, Alyami, Esmael M., Peng, Ching-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693507/
https://www.ncbi.nlm.nih.gov/pubmed/35424143
http://dx.doi.org/10.1039/d0ra10263f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693507/
https://www.ncbi.nlm.nih.gov/pubmed/35424143
http://dx.doi.org/10.1039/d0ra10263f

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