Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence

A highly efficient one-pot procedure combining conjugate addition of Grignard reagents to (2-nitroalkenyl)indoles and sub-sequent Brønsted acid-assisted spirocyclization allowed for preparation of 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically selective fashion. Utilization of alkyl Grign...

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Detalles Bibliográficos
Autores principales: Aksenov, Alexander V., Aksenov, Dmitrii A., Aksenov, Nicolai A., Skomorokhov, Anton A., Aleksandrova, Elena V., Rubin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693578/
https://www.ncbi.nlm.nih.gov/pubmed/35424118
http://dx.doi.org/10.1039/d0ra10219a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693578/
https://www.ncbi.nlm.nih.gov/pubmed/35424118
http://dx.doi.org/10.1039/d0ra10219a

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