LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators

Pantothenate kinase (PANK) is the critical regulator of intracellular levels of coenzyme A and has emerged as an attractive target for treating neurological and metabolic disorders. This report describes the optimization, synthesis, and full structure–activity relationships of a new chemical series...

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Detalles Bibliográficos
Autores principales: Sharma, Lalit Kumar, Yun, Mi Kyung, Subramanian, Chitra, Tangallapally, Rajendra, Jackowski, Suzanne, Rock, Charles O., White, Stephen W., Lee, Richard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693618/
https://www.ncbi.nlm.nih.gov/pubmed/34814071
http://dx.doi.org/10.1016/j.bmc.2021.116504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693618/
https://www.ncbi.nlm.nih.gov/pubmed/34814071
http://dx.doi.org/10.1016/j.bmc.2021.116504

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