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LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators
Pantothenate kinase (PANK) is the critical regulator of intracellular levels of coenzyme A and has emerged as an attractive target for treating neurological and metabolic disorders. This report describes the optimization, synthesis, and full structure–activity relationships of a new chemical series...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693618/ https://www.ncbi.nlm.nih.gov/pubmed/34814071 http://dx.doi.org/10.1016/j.bmc.2021.116504 |