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Efficient access to 3′-O-phosphoramidite derivatives of tRNA related N(6)-threonylcarbamoyladenosine (t(6)A) and 2-methylthio-N(6)-threonylcarbamoyladenosine (ms(2)t(6)A)
An efficient method of ureido linkage formation during epimerization-free one-pot synthesis of protected hypermodified N(6)-threonylcarbamoyladenosine (t(6)A) and its 2-SMe analog (ms(2)t(6)A) was developed. The method is based on a Tf(2)O-mediated direct conversion of the N-Boc-protecting group of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693639/ https://www.ncbi.nlm.nih.gov/pubmed/35424152 http://dx.doi.org/10.1039/d0ra09803e |