Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs

Platelet transfusions are critical for severe thrombocytopenia but depend on blood donors. The shortage of donors and the potential of universal HLA-null platelet products have stimulated research on the ex vivo differentiation of human pluripotent stem cells (hPSCs) to platelets. We recently establ...

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Detalles Bibliográficos
Autores principales: Sone, Masamitsu, Nakamura, Sou, Umeda, Sachiko, Ginya, Harumi, Oshima, Motohiko, Kanashiro, Maria Alejandra, Paul, Sudip Kumar, Hashimoto, Kanae, Nakamura, Emiri, Harada, Yasuo, Tsujimura, Kyoko, Saraya, Atsunori, Yamaguchi, Tomoyuki, Sugimoto, Naoshi, Sawaguchi, Akira, Iwama, Atsushi, Eto, Koji, Takayama, Naoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693651/
https://www.ncbi.nlm.nih.gov/pubmed/34861163
http://dx.doi.org/10.1016/j.stemcr.2021.11.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693651/
https://www.ncbi.nlm.nih.gov/pubmed/34861163
http://dx.doi.org/10.1016/j.stemcr.2021.11.001

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