IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock

Severe infection can dramatically alter blood production, but the mechanisms driving hematopoietic stem and progenitor cell (HSC/HSPC) loss have not been clearly defined. Using Ixodes ovatus Ehrlichia (IOE), a tick-borne pathogen that causes severe shock-like illness and bone marrow (BM) aplasia, ty...

Descripción completa

Detalles Bibliográficos
Autores principales: Howard, Jennifer E., Smith, Julianne N.P., Fredman, Gabrielle, MacNamara, Katherine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693653/
https://www.ncbi.nlm.nih.gov/pubmed/34798063
http://dx.doi.org/10.1016/j.stemcr.2021.10.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693653/
https://www.ncbi.nlm.nih.gov/pubmed/34798063
http://dx.doi.org/10.1016/j.stemcr.2021.10.011

Ejemplares similares