Characterizing the structure–activity relationships of natural products, tanshinones, reveals their mode of action in inhibiting spleen tyrosine kinase

The cytosolic non-receptor protein kinase, spleen tyrosine kinase (SYK), is an attractive drug target in autoimmune, inflammatory disorder, and cancers indications. Here, we employed pharmacophore-based drug screening combined with biochemical assay and molecular dynamics (MD) simulations to identif...

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Detalles Bibliográficos
Autores principales: Tung, Min-Che, Tsai, Keng-Chang, Fung, Kit-Man, Don, Ming-Jaw, Tseng, Tien-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693659/
https://www.ncbi.nlm.nih.gov/pubmed/35424194
http://dx.doi.org/10.1039/d0ra08769f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693659/
https://www.ncbi.nlm.nih.gov/pubmed/35424194
http://dx.doi.org/10.1039/d0ra08769f

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