Pharmacophore modeling and virtual screening studies for discovery of novel farnesoid X receptor (FXR) agonists

Farnesoid X receptor (FXR) agonists would be considered as an important therapeutic strategy for several chronic liver and metabolic diseases. Here we have employed an integrated virtual screening by combining ligand-based pharmacophore mapping and molecular docking to identify novel nonsteroidal FX...

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Detalles Bibliográficos
Autores principales: Zhao, Shizhen, Peng, Wenjing, Li, Xinping, Wang, Le, Yin, Wenbo, Wang, Yan-Dong, Hou, Ruifang, Chen, Wei-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693749/
https://www.ncbi.nlm.nih.gov/pubmed/35424145
http://dx.doi.org/10.1039/d0ra09320c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693749/
https://www.ncbi.nlm.nih.gov/pubmed/35424145
http://dx.doi.org/10.1039/d0ra09320c

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