Cargando…

Modulating adult neurogenesis affects synaptic plasticity and cognitive functions in mouse models of Alzheimer's disease

New neurons are abnormal in the adult hippocampus of Alzheimer's disease (AD) mouse models. The effects of modulating adult neurogenesis on AD pathogenesis differ from study to study. We reported recently that ablation of adult neural stem cells (aNSCs) was associated with improved memory in AD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xiaoqin, Wei, Xiaojie, Mei, Yufei, Wang, Dongpi, Wang, Jing, Zhang, Yiping, Li, Xuekun, Gu, Yan, Peng, Guoping, Sun, Binggui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693766/ https://www.ncbi.nlm.nih.gov/pubmed/34861165 http://dx.doi.org/10.1016/j.stemcr.2021.11.003

Ejemplares similares

Ablating Adult Neural Stem Cells Improves Synaptic and Cognitive Functions in Alzheimer Models
por: Zhang, Xiaoqin, et al.
Publicado: (2020)

Response to questioning the evidence for a Janus-faced nature of adult neurogenesis in Alzheimer's disease
por: Zhang, Xiaoqing, et al.
Publicado: (2021)

Enhanced Expression of Markers for Astrocytes in the Brain of a Line of GFAP-TK Transgenic Mice
por: Zhang, Xiaoqin, et al.
Publicado: (2017)

Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein
por: Pan, Hongyu, et al.
Publicado: (2016)

Dynamic learning and memory, synaptic plasticity and neurogenesis: an update
por: Stuchlik, Ales
Publicado: (2014)

Editorial: Neurorepair Strategies to Induce Angiogenesis, Neurogenesis and Synaptic Plasticity
por: Klempin, Friederike, et al.
Publicado: (2021)

The multifunctional Staufen proteins: conserved roles from neurogenesis to synaptic plasticity
por: Heraud-Farlow, Jacki E., et al.
Publicado: (2014)

Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity
por: Gilbert, James, et al.
Publicado: (2017)

The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation
por: Kempf, Stefan J, et al.
Publicado: (2014)

Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
por: Hwang, Kyoung-Doo, et al.
Publicado: (2017)

The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model
por: Buendía, Débora, et al.
Publicado: (2022)

Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity
por: Dong, Suzhen, et al.
Publicado: (2012)

Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity
por: Zhu, XingLiang, et al.
Publicado: (2023)

Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease
por: Lee, Linda, et al.
Publicado: (2014)

Disrupted‐in‐schizophrenia‐1 protects synaptic plasticity in a transgenic mouse model of Alzheimer’s disease as a mitophagy receptor
por: Wang, Zhao‐Tao, et al.
Publicado: (2018)

Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity
por: Joo, Yuyoung, et al.
Publicado: (2020)

Oxidative Stress in Depression: The Link with the Stress Response, Neuroinflammation, Serotonin, Neurogenesis and Synaptic Plasticity
por: Correia, Ana Salomé, et al.
Publicado: (2023)

Magnesium Protects Cognitive Functions and Synaptic Plasticity in Streptozotocin-Induced Sporadic Alzheimer’s Model
por: Xu, Zhi-Peng, et al.
Publicado: (2014)

β-Amyrin Ameliorates Alzheimer’s Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus
por: Park, Hye Jin, et al.
Publicado: (2020)

Corrigendum: Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer’s disease
por: Lee, Linda, et al.
Publicado: (2015)

Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease
por: Zhou, Yujuan, et al.
Publicado: (2023)

Deficits in N-Methyl-D-Aspartate Receptor Function and Synaptic Plasticity in Hippocampal CA1 in APP/PS1 Mouse Model of Alzheimer’s Disease
por: Xu, Le, et al.
Publicado: (2021)

The Implication of STEP in Synaptic Plasticity and Cognitive Impairments in Alzheimer’s Disease and Other Neurological Disorders
por: Mahaman, Yacoubou Abdoul Razak, et al.
Publicado: (2021)

Vitamin D Improves Neurogenesis and Cognition in a Mouse Model of Alzheimer’s Disease
por: Morello, Maria, et al.
Publicado: (2018)

Discovery of drug lead compounds for Anti-Alzheimer's disease on the basis of synaptic plasticity
por: Wang, Heyu, et al.
Publicado: (2023)

Involvement of LIN28A in Wnt-dependent regulation of hippocampal neurogenesis in the aging brain
por: Hu, Zhechun, et al.
Publicado: (2022)

Global trends and prospects about synaptic plasticity in Alzheimer’s disease: a bibliometric analysis
por: Zhang, Yingying, et al.
Publicado: (2023)

Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease
por: Sharma, Shiv K.
Publicado: (2010)

Targeting Synaptic Plasticity in Experimental Models of Alzheimer’s Disease
por: Mango, Dalila, et al.
Publicado: (2019)

The Role of Additive Neurogenesis and Synaptic Plasticity in a Hippocampal Memory Model with Grid-Cell Like Input
por: Appleby, Peter A., et al.
Publicado: (2011)

Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis
por: Murray, Karl D., et al.
Publicado: (2020)

Osthole improves synaptic plasticity in the hippocampus and cognitive function of Alzheimer's disease rats via regulating glutamate☆
por: Dong, Xiaohua, et al.
Publicado: (2012)

Calcium and Neurogenesis in Alzheimer's Disease
por: Wang, Jun Ming, et al.
Publicado: (2010)

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease
por: Ma, Tao, et al.
Publicado: (2010)

Commentary: The Flavonoid Baicalein Rescues Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer’s Disease
por: Chirumbolo, Salvatore, et al.
Publicado: (2016)

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model
por: Kempf, Stefan J., et al.
Publicado: (2016)

Transcranial Magneto-Acoustic Stimulation Attenuates Synaptic Plasticity Impairment through the Activation of Piezo1 in Alzheimer’s Disease Mouse Model
por: Chu, Fangxuan, et al.
Publicado: (2023)

Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model
por: Li, Wei, et al.
Publicado: (2014)

Arc-Mediated Synaptic Plasticity Regulates Cognitive Function in a Migraine Mouse Model
por: Hu, Luyu, et al.
Publicado: (2023)

Emerging Link between Alzheimer's Disease and Homeostatic Synaptic Plasticity
por: Jang, Sung-Soo, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_j66qc6nf5e5uuv28n26o8ar04q