Molecular Docking-Based Screening for Novel Inhibitors of the Human Immunodeficiency Virus Type 1 Protease that Effectively Reduce the Viral Replication in Human Cells

Therapeutic pressure by protease inhibitors (PIs) contributes to accumulation of mutations in the HIV type 1 (HIV-1) protease (PR) leading to development of drug resistance with subsequent therapy failure. Current PIs target the active site of PR in a competitive manner. Identification of molecules...

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Detalles Bibliográficos
Autores principales: Mavian, Carla, Coman, Roxana M, Zhang, Xinrui, Pomeroy, Steve, Ostrov, David A., Dunn, Ben M, Sleasman, John W., Goodenow, Maureen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694022/
https://www.ncbi.nlm.nih.gov/pubmed/34950525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694022/
https://www.ncbi.nlm.nih.gov/pubmed/34950525

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