Vascular K(ATP) channel structural dynamics reveal regulatory mechanism by Mg-nucleotides

Vascular tone is dependent on smooth muscle K(ATP) channels comprising pore-forming Kir6.1 and regulatory SUR2B subunits, in which mutations cause Cantú syndrome. Unique among K(ATP) isoforms, they lack spontaneous activity and require Mg-nucleotides for activation. Structural mechanisms underlying...

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Detalles Bibliográficos
Autores principales: Sung, Min Woo, Yang, Zhongying, Driggers, Camden M., Patton, Bruce L., Mostofian, Barmak, Russo, John D., Zuckerman, Daniel M., Shyng, Show-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694068/
https://www.ncbi.nlm.nih.gov/pubmed/34711681
http://dx.doi.org/10.1073/pnas.2109441118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694068/
https://www.ncbi.nlm.nih.gov/pubmed/34711681
http://dx.doi.org/10.1073/pnas.2109441118

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