Selective destabilization of polypeptides synthesized from NMD-targeted transcripts

The translation of mRNAs that contain a premature termination codon (PTC) generates truncated proteins that may have toxic dominant negative effects. Nonsense-mediated decay (NMD) is an mRNA surveillance pathway that degrades PTC-containing mRNAs to limit the production of truncated proteins. NMD ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Chu, Vincent, Feng, Qing, Lim, Yang, Shao, Sichen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694075/
https://www.ncbi.nlm.nih.gov/pubmed/34586879
http://dx.doi.org/10.1091/mbc.E21-08-0382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694075/
https://www.ncbi.nlm.nih.gov/pubmed/34586879
http://dx.doi.org/10.1091/mbc.E21-08-0382

Ejemplares similares