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Selective destabilization of polypeptides synthesized from NMD-targeted transcripts

The translation of mRNAs that contain a premature termination codon (PTC) generates truncated proteins that may have toxic dominant negative effects. Nonsense-mediated decay (NMD) is an mRNA surveillance pathway that degrades PTC-containing mRNAs to limit the production of truncated proteins. NMD ac...

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Detalles Bibliográficos
Autores principales:	Chu, Vincent, Feng, Qing, Lim, Yang, Shao, Sichen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694075/ https://www.ncbi.nlm.nih.gov/pubmed/34586879 http://dx.doi.org/10.1091/mbc.E21-08-0382

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