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Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptid...

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Detalles Bibliográficos
Autores principales: Frenkel-Pinter, Moran, Sargon, Alyssa B., Glass, Jennifer B., Hud, Nicholas V., Williams, Loren Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694183/
https://www.ncbi.nlm.nih.gov/pubmed/35424306
http://dx.doi.org/10.1039/d0ra07965k