Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptid...

Descripción completa

Detalles Bibliográficos
Autores principales: Frenkel-Pinter, Moran, Sargon, Alyssa B., Glass, Jennifer B., Hud, Nicholas V., Williams, Loren Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694183/
https://www.ncbi.nlm.nih.gov/pubmed/35424306
http://dx.doi.org/10.1039/d0ra07965k
_version_ 1784619296302825472
author Frenkel-Pinter, Moran
Sargon, Alyssa B.
Glass, Jennifer B.
Hud, Nicholas V.
Williams, Loren Dean
author_facet Frenkel-Pinter, Moran
Sargon, Alyssa B.
Glass, Jennifer B.
Hud, Nicholas V.
Williams, Loren Dean
author_sort Frenkel-Pinter, Moran
collection PubMed
description Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.
format Online
Article
Text
id pubmed-8694183
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-86941832022-04-13 Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine Frenkel-Pinter, Moran Sargon, Alyssa B. Glass, Jennifer B. Hud, Nicholas V. Williams, Loren Dean RSC Adv Chemistry Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution. The Royal Society of Chemistry 2021-01-18 /pmc/articles/PMC8694183/ /pubmed/35424306 http://dx.doi.org/10.1039/d0ra07965k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Frenkel-Pinter, Moran
Sargon, Alyssa B.
Glass, Jennifer B.
Hud, Nicholas V.
Williams, Loren Dean
Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine
title Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine
title_full Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine
title_fullStr Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine
title_full_unstemmed Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine
title_short Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine
title_sort transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8694183/
https://www.ncbi.nlm.nih.gov/pubmed/35424306
http://dx.doi.org/10.1039/d0ra07965k
work_keys_str_mv AT frenkelpintermoran transitionmetalsenhanceprebioticdepsipeptideoligomerizationreactionsinvolvinghistidine
AT sargonalyssab transitionmetalsenhanceprebioticdepsipeptideoligomerizationreactionsinvolvinghistidine
AT glassjenniferb transitionmetalsenhanceprebioticdepsipeptideoligomerizationreactionsinvolvinghistidine
AT hudnicholasv transitionmetalsenhanceprebioticdepsipeptideoligomerizationreactionsinvolvinghistidine
AT williamslorendean transitionmetalsenhanceprebioticdepsipeptideoligomerizationreactionsinvolvinghistidine

Ejemplares similares